Associations for the reciprocal and mutual sharing of advantages and disadvantages: applicative insights in prevention or cure of AIDS, cancer and leprous diseases

The merging of a new living system, healthy like a neurone or pathologic like a cancer clone, whatever its type of organisation, is always a transgression of older ones. It is achieved with the juxtapositions and encasements of previous systems. The new Wholeness is both more and less than the sum of its parts. It merges from the simultaneous metamorphoses of the partners that maintain their identity and their half-autonomy by the preservation of their individual and collective boundaries and their selforganisation (like the Eukaryotic cell, which merged from Monera [9]. The shuttle [8] of a step of organisation “i” to a higher adjacent one “i+1” is the result of the merging of a new spatial and temporal network, whatever its mode of integration, through the birth of an Association for the Reciprocal and Mutual Sharing of Advantages and of Disadvantages (ARMSADA), like a Lichen Organism. But, all the partners must loss simultaneously the capacity to destroy the others. Each advantage for a partner is always a disadvantage for all the others and reciprocally. No one partner is a winner, all are “winner and loser”: ARMSADA is an association "for the best and the worst". The gain is only for the Wholeness! There is only one rule to survive: "to transform disadvantages into advantages" and "to prevent advantages from turning to disadvantages". When the ecoexotope (EXT) is changing, a disadvantage can turn to an advantage and conversely. To survive it is "to eat and not to be eaten". Preys or hosts and predators or parasites (like immune cells and HIV) struggle each other in a war without mercy. Each defensive innovation of a prey is followed by an aggressive one of its predators. “To attack” is never the best defence, but “to change” of trophic network. Only the metamorphosis of the endophysiotope (ENT) makes possible to self-control the dangers. In order that one survives, it is necessary that the others survive first, and reciprocally. During the genesis of a leguminous nodule, the host plant part metamorphoses into a tumour and the Bacteria metamorphose simultaneously into bacteroids. The fate of a cancer or HIV-infected cell, like that of a bacterium infected with a phage, is depending on the interactive percolation with its invading virus. That indeed explains the heterogeneity of a disease (cancer or AIDS), its evolutions and the diversity of the potential hosts: "the way is, both, the cause and the consequence of the history." As the previously proposed curative AIDS vaccine, to built with HIV engineered stem cells [10], the application of this systemic paradigm allows the design of new vaccines, like a curative cancer vaccine and a preventive leprous one.